Endocrine Abstracts

Patients (pts) with hypoparathyroidism (HypoPT) are at risk to develop renal failure possibly caused by hypercalciuria and nephrocalcinosis. We retrospectively evaluated the data of 711 Patients with HypoPT in 3 endocrine centres in Germany.Methods: Records of 711 pts with HypoPT were reviewed. Patients were predominantly female (n=592, male: n=119; age 50.9±14.1 years, range 12 – 99 years). The following parameters were docum...

Care of patients (pts.) with hypoparathyroidism (HypoPT) is a challenge, because pts. are usually not treated with the absent hormone, but with several forms of vitamine D. We retrospectively evaluated the data of pts. with HypoPT in three endocrine centres in Germany.Methods: Records of 711 pts. with HypoPT (Centre 1 (C1): n=381, C2: n=253, C3: n=77) were reviewed (female: 592, male: 119). The following data under treatment (t...

Introduction: Patients with hypoparathyroidism (hypoPT) suffer from a number of complaints and reduced quality of life (QoL) besides having serum values for disease-specific parameters in the target range. To be able to quantify symptoms in hypoPT patients we lately developed a disease-specific questionnaire, the Hypoparathyroidism patient questionnaire with 28 items (HPQ28). The aim of this study was to present normative values for the HPQ28.Methods: A ...

Introduction: Hypoparathyroidism (hypoPT) is characterized by inadequately low circulating concentrations of parathyroid hormone (PTH) followed by low calcium and increased phosphate levels in the blood. Patients with hypoPT suffer from a number of complications and complaints including infections, neuro-psychiatric diseases, abnormal bone architecture impaired muscle function and reduced quality of life. Due to the complexity of the various clinical manifestations there is a ...

Introduction: Turner syndrome (TS) is characterized by the complete or partial loss of one X chromosome and associated with a wide range of clinical manifestations. The clinical appearance depends on the specific karyotype, which may include different mosaic forms. Main features of almost all the karyotypes are short stature and delayed or absent puberty. Adult women in particular are at high risk of developing cardiac complications, metabolic syndrome, increased liver enzyme ...

Introduction: Physiological glucocorticoids play an essential role in bone formation but can cause osteoporosis if present in excess. The key enzyme converting inactive cortisone into the active cortisol and vice versa is 11-beta-hydroxy-steroid-dehydrogenase (11β-HSD1). We have reported that genetic variations in the HSD11B1 gene correlate with increased cortisol levels in dexamethasone suppression and with changes in bone mineral density (BMD) suggesting indivi...

In hypoparathyroidism (HypoPT), patients suffer severely from reduced quality of life. The complexity of HypoPT demands a disease-specific control instrument to characterize symptom load. We employed a newly developed disease-specifichypoparathyroid patient questionnaire (the HPQ 40/28) to investigate and quantify HypoPT patients’ complaints and contributing factors. In this cross-sectional, two-center study, patients with postsurgical HypoPT (n = 49) were m...

Significant knowledge gaps exist regarding the humanistic effects of hypoparathyroidism, a rare, debilitating disorder. We report results from a global survey to characterise the burden of hypoparathyroidism from the patient perspective. An anonymous survey was conducted in patients with uncontrolled chronic hypoparathyroidism (as determined by patients’ report of persistent symptoms and/or poorly controlled calcium levels as told by their physician) despite receiving con...

Although chronic hypoparathyroidism is known to negatively affect health-related quality of life (HRQoL), burden of illness is less well defined in patients whose disease is not adequately controlled on conventional therapy. We report burden of illness for the European subset of a patient survey in 13 countries globally. 398 adults with chronic hypoparathyroidism not adequately controlled on conventional therapy (recruited by treating physician or patient association) complete...

Significant knowledge gaps exist regarding the humanistic effects of chronic hypoparathyroidism (HPT), a rare, debilitating condition. We provide interim results from a global survey conducted to characterise the burden associated with chronic HPT from the patient perspective. An anonymous, self-reported survey (online or paper) was conducted in patients with chronic HPT, not adequately controlled with standard therapy by self-perception, from 12 countries through physicians o...